Flunisine meglumine is a strong cyclooxygenase inhibitor with analgesic, antipyretic, anti - inflammatory and anti - rheumatic effects. Analgesic effect is caused by inhibiting the synthesis of peripheral prostaglandins or their nociceptive sensitizers or their combined action, thereby blocking the conduction of nociceptive impulses. The anti-inflammatory effect of peripheral tissues may be caused by inhibiting cyclooxygenase, reducing the formation of prostaglandin precursors, and inhibiting the local inflammatory response caused by other mediators. Flunisine does not affect gastrointestinal motility in horses but may improve hemodynamics in septic shock animals.